WNT/β-catenin Pathway Activation Correlates with Immune Exclusion across Human Cancers.

Jason J LukeRiyue BaoRandy F SweisStefani SprangerThomas F Gajewski

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

Activation of tumor-intrinsic WNT/β-catenin signaling is enriched in non-T-cell-inflamed tumors. These data provide a strong rationale for development of pharmacologic inhibitors of this pathway with the aim of restoring immune cell infiltration and augmenting immunotherapy.See related commentary by Dangaj et al., p. 2943.

Keyphrases

cell proliferation
stem cells
endothelial cells
clinical trial
induced pluripotent stem cells
big data
pluripotent stem cells
machine learning
young adults