Monoclonal antibody-mediated immunosuppression enables long-term survival of transplanted human neural stem cells in mouse brain.
Lisa M McGinleyKevin S ChenShayna N MasonDiana M RiganJacquelin F KwentusJohn M HayesEmily D GlassEvan L ReynoldsGeoffrey G MurphyEva L FeldmanPublished in: Clinical and translational medicine (2022)
This study demonstrates an effective immunosuppression protocol for preclinical testing of stem cell therapies. A transition towards antibody-based strategies may be advantageous by enabling stem cell survival in preclinical studies that could inform future clinical trials.