Influence of the maternal high-intensity-interval-training on the cardiac Sirt6 and lipid profile of the adult male offspring in rats.
Reihaneh MohammadkhaniNeda KhalediHamid RajabiIraj SalehiAlireza KomakiPublished in: PloS one (2020)
The susceptibility to cardiovascular disease in offspring could be reduced prior to birth through maternal intervention, before and during pregnancy. We evaluated whether the initiation periods of maternal exercise in preconception and pregnancy periods induce beneficial effects in the adult male offspring. Thirty-two female rats were divided into control and exercise groups. The exercise groups involve exercise before pregnancy or the preconception periods, exercise during pregnancy, and exercise before and during pregnancy. The mothers in the exercise groups were run on the treadmill in different periods. Then the birth weight and weekly weight gain of male offspring were measured, and the blood and left ventricle tissue of samples were collected for analysis of the Sirtuin 6 (Sirt6) and insulin growth factor-2 (IGF-2) gene expression, serum levels of low-density lipoprotein (LDL), high-density lipoprotein (HDL), cholesterol (Cho), and triglycerides (TG). There was no significant difference in the birth weight of offspring groups (P = 0.246) while maternal HIIT only during pregnancy leads to reduce weekly weight gain of offspring. Our data showed that Sirt6 and IGF-2 gene expression was increased (P = 0.017) and decreased (P = 0.047) by maternal exercise prior to and during pregnancy, respectively. Also, the serum level of LDL (p = 0.002) and Cho (P = 0.007) were significantly decreased and maternal exercise leads to improves the running speed of the adult male offspring (p = 0.0176). This study suggests that maternal HIIT prior to and during pregnancy have positive intergenerational consequence in the health and physical readiness of offspring.
Keyphrases
- birth weight
- weight gain
- high intensity
- gestational age
- high fat diet
- physical activity
- gene expression
- body mass index
- low density lipoprotein
- resistance training
- cardiovascular disease
- preterm birth
- pregnancy outcomes
- high density
- healthcare
- weight loss
- public health
- oxidative stress
- type diabetes
- randomized controlled trial
- dna methylation
- pulmonary hypertension
- skeletal muscle
- insulin resistance
- coronary artery
- left ventricular
- climate change
- cell proliferation
- coronary artery disease
- data analysis
- pulmonary artery
- health information
- risk assessment
- deep learning
- electronic health record