Severe acute respiratory syndrome coronavirus 2 as a potential cause of type 1 diabetes facilitated by spike protein receptor binding domain attachment to human islet cells: An illustrative case study and experimental data.
Nisha VenkateshNatalie AstburyMerlin C ThomasCarlos J RosadoEvan PappasBalasubramanian KrishnamurthyRichard J MacIsaacThomas W H KayHelen E ThomasDavid Norman O'NealPublished in: Diabetic medicine : a journal of the British Diabetic Association (2021)
Although a causal basis remains to be established, our case and in vitro data highlight a potential mechanism by which SARS-CoV-2 infection may result in antibody-negative type 1 diabetes.
Keyphrases
- respiratory syndrome coronavirus
- type diabetes
- sars cov
- electronic health record
- coronavirus disease
- induced apoptosis
- glycemic control
- endothelial cells
- big data
- binding protein
- human health
- insulin resistance
- cell cycle arrest
- induced pluripotent stem cells
- machine learning
- endoplasmic reticulum stress
- oxidative stress
- small molecule
- amino acid
- pluripotent stem cells
- signaling pathway
- artificial intelligence
- cell death
- climate change