Proteomic Associations of NT-proBNP (N-Terminal Pro-B-Type Natriuretic Peptide) in Heart Failure With Preserved Ejection Fraction.
Joe David AzzoMarie-Joe DibLoukas ZagkosLei ZhaoZhaoqing WangChing-Pin ChangChristina EbertOday SalmanSushrima GanPayman ZamaniJordana B CohenVanessa P M van EmpelArthur Mark RichardsAli JavaheriDouglas L MannErnst R RietzschelPeter H SchaferDietmar A SeiffertDipender GillStephen BurgessFrancisco Ramírez-ValleDavid A GordonThomas P CappolaJulio Alonso ChirinosPublished in: Circulation. Heart failure (2024)
Circulating NT-proBNP levels exhibit prominent proteomic associations in HFpEF. Our findings suggest that higher NT-proBNP levels in HFpEF are a marker of fibrosis and inflammation. These findings will aid the interpretation of NT-proBNP levels in HFpEF and may guide the selection of participants in future HFpEF clinical trials.