High-throughput multivariable Mendelian randomization analysis prioritizes apolipoprotein B as key lipid risk factor for coronary artery disease.

Verena Zuber Dipender Gill Mika Ala-Korpela Claudia LangenbergAdam ButterworthLeonardo BottoloStephen Burgess

Published in: International journal of epidemiology (2021)

Our agnostic genetic investigation prioritizes ApoB across all datasets considered, suggesting that ApoB, representing the total number of hepatic-derived lipoprotein particles, is the primary lipid determinant of CAD.

Keyphrases

coronary artery disease
high throughput
fatty acid
percutaneous coronary intervention
cardiovascular disease
heart failure
rna seq
dna methylation
copy number
low density lipoprotein
aortic stenosis
transcatheter aortic valve replacement