Hyperoside Inhibits RNF8-mediated Nuclear Translocation of β-catenin to Repress PD-L1 Expression and Prostate Cancer.

Jie ChenYi ZhaoXiaoli WangLong ZangDengke YinSong Tan

Published in: Anti-cancer agents in medicinal chemistry (2024)

Hyperoside exerts its anti-PCa effect by reducing RNF8 protein, inhibiting nuclear translocation of β-catenin, and disrupting the Wnt/β-catenin pathway, in turn reducing the expression of PD-L1 and improving Jurkat cell immunity.

Keyphrases

prostate cancer
cell proliferation
epithelial mesenchymal transition
poor prognosis
binding protein
radical prostatectomy
single cell
signaling pathway
dna damage response
stem cells
fluorescent probe
sensitive detection
protein protein
amino acid
oxidative stress
bone marrow
quantum dots
dna repair
single molecule