Double-strand DNA breaks and repair response in human immature oocytes and their relevance to meiotic resumption.

Giovanni CoticchioMariabeatrice Dal CantoMaria Cristina GuglielmoDavid F AlbertiniMario Mignini RenziniMaria MerolaMonia LainManuela SottocornolaElena De PontiRubens Fadini

Published in: Journal of assisted reproduction and genetics (2015)

The present data document the existence of double-strand DNA breaks (DSBs) in human immature oocytes. Also, they are consistent with the hypothesis that insults to DNA integrity may be an important factor affecting meiotic resumption.

Keyphrases

circulating tumor
endothelial cells
cell free
single molecule
induced pluripotent stem cells
pluripotent stem cells
nucleic acid
machine learning
big data
deep learning