DNA Methylation Regulates a Set of Long Non-Coding RNAs Compromising Hepatic Identity during Hepatocarcinogenesis.
Miriam RecaldeMaría Gárate-RascónJosé María HerranzMaría ElizaldeMaría AzkonaJuan Pablo UnfriedLoreto BoixMaria ReigBruno SangroMaite G Férnandez-BarrenaPuri FortesMatias A AvilaCarmen BerasainMaría ArechederraPublished in: Cancers (2022)
Our results demonstrate that the selected Top35 LNDH are not only part of the genes that compose the hepatic differentiated signature but participate in its establishment. Moreover, their downregulation through DNA methylation occurs during the process of hepatocarcinogenesis compromising hepatocellular differentiation and HCC patients' prognosis.