Molecular Mechanisms of IL18 in Disease.
Kyosuke YamanishiMasaki HataNaomi GamachiYuko WatanabeChiaki YamanishiHaruki OkamuraHisato MatsunagaPublished in: International journal of molecular sciences (2023)
Interleukin 18 (IL18) was originally identified as an inflammation-induced cytokine that is secreted by immune cells. An increasing number of studies have focused on its non-immunological functions, with demonstrated functions for IL18 in energy homeostasis and neural stability. IL18 is reportedly required for lipid metabolism in the liver and brown adipose tissue. Furthermore, IL18 ( Il18 ) deficiency in mice leads to mitochondrial dysfunction in hippocampal cells, resulting in depressive-like symptoms and cognitive impairment. Microarray analyses of Il18 -/- mice have revealed a set of genes with differential expression in liver, brown adipose tissue, and brain; however, the impact of IL18 deficiency in these tissues remains uncertain. In this review article, we discuss these genes, with a focus on their relationships with the phenotypic disease traits of Il18 -/- mice.
Keyphrases
- adipose tissue
- cognitive impairment
- gene expression
- oxidative stress
- induced apoptosis
- type diabetes
- metabolic syndrome
- genome wide
- bipolar disorder
- transcription factor
- high fat diet
- physical activity
- multiple sclerosis
- high fat diet induced
- cell proliferation
- fatty acid
- brain injury
- endothelial cells
- subarachnoid hemorrhage
- sleep quality
- cell cycle arrest
- stress induced
- bioinformatics analysis
- drug induced