The Hippo signaling pathway plays a pivotal role in regulating cell growth and organ size. Its regulatory effects on hepatocellular carcinoma (HCC) encompass diverse aspects, including cell proliferation, invasion and metastasis, tumor drug resistance, metabolic reprogramming, immunomodulatory effects and autophagy. Yes‑associated protein 1 (YAP1), a potent transcriptional coactivator and a major downstream target tightly controlled by the Hippo pathway, is influenced by various molecules and pathways. The expression of YAP1 in different cell types within the liver tumor microenvironment exerts varying effects on tumor outcomes, warranting careful consideration. Therefore, research on YAP1‑targeted therapies merits attention. This review discusses the composition and regulation mechanism of the Hippo/YAP1 signaling pathway and its relationship with HCC, offering insights for future research and cancer prevention strategies.
Keyphrases
- signaling pathway
- pi k akt
- cell proliferation
- epithelial mesenchymal transition
- induced apoptosis
- transcription factor
- cell death
- poor prognosis
- gene expression
- stem cells
- oxidative stress
- papillary thyroid
- single cell
- squamous cell carcinoma
- current status
- skeletal muscle
- insulin resistance
- heat shock
- long non coding rna
- heat stress