Fibronectin urothelial gene expression as a new reliable biomarker for early detection of local toxicity secondary to adjuvant intravesical therapy for non-muscle invasive bladder cancer.
Fabrizio Di MaidaCristina Scalici GesolfoRiccardo TelliniAndrea MariChiara SanfilippoLuca LambertiniAntonio Andrea GrossoMarco CariniAndrea MinerviniVincenzo SerrettaPublished in: Therapeutic advances in urology (2021)
Our study validated the correlation between FN expression and urothelial damage. BCG seems to induce a urothelial activation with FN overexpression during adjuvant intravesical therapy. Grade of toxicity was related to FN expression.