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Fibronectin urothelial gene expression as a new reliable biomarker for early detection of local toxicity secondary to adjuvant intravesical therapy for non-muscle invasive bladder cancer.

Fabrizio Di MaidaCristina Scalici GesolfoRiccardo TelliniAndrea MariChiara SanfilippoLuca LambertiniAntonio Andrea GrossoMarco CariniAndrea MinerviniVincenzo Serretta
Published in: Therapeutic advances in urology (2021)
Our study validated the correlation between FN expression and urothelial damage. BCG seems to induce a urothelial activation with FN overexpression during adjuvant intravesical therapy. Grade of toxicity was related to FN expression.
Keyphrases
  • muscle invasive bladder cancer
  • urinary tract
  • gene expression
  • poor prognosis
  • high grade
  • oxidative stress
  • early stage
  • dna methylation
  • binding protein
  • cell proliferation
  • long non coding rna
  • stem cells
  • bone marrow