A Single-Short Partial Reprogramming of the Endothelial Cells decreases Blood Pressure via attenuation of EndMT in Hypertensive Mice.
Laena PernomianEmily W WaigiVi NguyenAhmed D MohammedTiago J da CostaMilene T FontesJason Lee KubinakAndrew V AitkenVinicia Campana BiancardiDavid A SinclairCameron G McCarthyYunguan WangWenbin TanCamilla Ferreira WenceslauPublished in: bioRxiv : the preprint server for biology (2024)
Overall, these data indicate that OSK treatment and EC reprogramming can decrease blood pressure and reverse hypertension-induced vascular damage.