Vancomycin-laden calcium phosphate-calcium sulfate composite allows bone formation in a rat infection model.

K Keely BoyleBranden SosaLiza OsagieKathleen TurajaneMathias P G BostromXu Yang

Published in: PloS one (2019)

When loaded with 10% of vancomycin, CaP/CaS and PMMA have the same efficacy for treatment and prevention of osteomyelitis. CaP/CaS enhances bone defect healing through improved bone remodeling in our osteomyelitis rat model.

Keyphrases

crispr cas
genome editing
bone mineral density
methicillin resistant staphylococcus aureus
soft tissue
drug delivery
bone regeneration
oxidative stress
combination therapy
wound healing