Innate defense regulator IDR-1018 activates human mast cells through G protein-, phospholipase C-, MAPK- and NF-ĸB-sensitive pathways.

Kensuke YanashimaPanjit ChieosilapathamEri YoshimotoKo OkumuraHideoki OgawaFrançois Niyonsaba

Published in: Immunologic research (2018)

We report that IDR-1018 stimulates various functions of human mast cells. IDR-1018-induced mast cell activation is mediated through G protein, PLC, MAPK and NF-κB pathways. IDR-1018 will be a useful therapeutic agent for wound healing.

Keyphrases

signaling pathway
endothelial cells
pi k akt
oxidative stress
immune response
high glucose
induced pluripotent stem cells
wound healing
lps induced
pluripotent stem cells
transcription factor
diabetic rats
toll like receptor