Tumour-associated microglia/macrophages predict poor prognosis in high-grade gliomas and correlate with an aggressive tumour subtype.

Mia Dahl Sørensen Rikke Hedegaard DahlrotH B BoldtS HansenB W Kristensen

Published in: Neuropathology and applied neurobiology (2017)

This is the first study to use automated quantitative immunofluorescence to determine the prognostic impact of TAMs. Our results suggest that M2-like TAMs hold an unfavourable prognostic value in high-grade gliomas and may contribute to a pro-tumourigenic microenvironment.

Keyphrases

high grade
poor prognosis
low grade
long non coding rna
stem cells
machine learning
deep learning
high resolution
high throughput
inflammatory response
neuropathic pain
anti inflammatory
spinal cord
mass spectrometry
spinal cord injury
single cell