Notch-Hes1 Signaling Regulates IL-17A+ γδ +T Cell Expression and IL-17A Secretion of Mouse Psoriasis-Like Skin Inflammation.

The spleen index, IL-17A+ γδ +T cell percentage, Hes1 mRNA expression, IL-17A serum concentration, and protein expression were all significantly higher in model mice than control mice, while dramatically reduced in intervention mice by DAPT treatment, which also obviously alleviated the target lesion score, epidermal hyperplasia, and dermal inflammatory cell infiltration of intervention mice. In vitro study demonstrated that DAPT treatment could result in dose-dependent decrease of IL-17A+ γδ +T cell percentage and IL-17A secretion in splenic single cells of model mice.