Coenzyme Q10: A Key Antioxidant in the Management of Diabetes-Induced Cardiovascular Complications-An Overview of Mechanisms and Clinical Evidence.
Fatemeh SamimiNasim NamiranianAli Sharifi-RigiMorvarid SiriOmid AbazariSanaz DastghaibPublished in: International journal of endocrinology (2024)
In conclusion, CoQ10 emerges as a promising natural therapeutic intervention for the comprehensive management of diabetes and its associated cardiovascular complications. Its multifaceted impacts on the Nrf2/Keap1/ARE pathway, oxidative stress, and metabolic regulation highlight its potential as an adjunct in the treatment of diabetes and related cardiovascular disorders. However, further extensive clinical investigations are necessary to fully establish its therapeutic potential and assess potential synergistic effects with other compounds.
Keyphrases
- oxidative stress
- type diabetes
- cardiovascular disease
- glycemic control
- diabetic rats
- randomized controlled trial
- risk factors
- high glucose
- dna damage
- induced apoptosis
- drug induced
- risk assessment
- metabolic syndrome
- cancer therapy
- small molecule
- signaling pathway
- anti inflammatory
- endothelial cells
- climate change
- endoplasmic reticulum stress
- smoking cessation