Abnormal immunolabelling of SMAD4 in cell block specimens to distinguish malignant and benign pancreatic cells.
Yoko MatsudaShikine EsakaAkemi SuzukiYuri HamashimaMasayuki ImaizumiMiho MatsukawaYuko FujiiJunko AidaKaiyo TakuboToshiyuki IshiwataMakoto NishimuraTomio AraiPublished in: Cytopathology : official journal of the British Society for Clinical Cytology (2018)
Decreased SMAD4 immunolabelling provided improved sensitivity as compared to negative SMAD4 immunolabelling; therefore, it is important to compare SMAD4 expression in a sample to its expression in normal cells. Abnormal SMAD4 labelling showed low sensitivity and high specificity; therefore, SMAD4 staining using EUS-FNA samples might be helpful to detect malignancies that possess SMAD4 gene abnormalities.