Login / Signup

Abnormal immunolabelling of SMAD4 in cell block specimens to distinguish malignant and benign pancreatic cells.

Yoko MatsudaShikine EsakaAkemi SuzukiYuri HamashimaMasayuki ImaizumiMiho MatsukawaYuko FujiiJunko AidaKaiyo TakuboToshiyuki IshiwataMakoto NishimuraTomio Arai
Published in: Cytopathology : official journal of the British Society for Clinical Cytology (2018)
Decreased SMAD4 immunolabelling provided improved sensitivity as compared to negative SMAD4 immunolabelling; therefore, it is important to compare SMAD4 expression in a sample to its expression in normal cells. Abnormal SMAD4 labelling showed low sensitivity and high specificity; therefore, SMAD4 staining using EUS-FNA samples might be helpful to detect malignancies that possess SMAD4 gene abnormalities.
Keyphrases