Variants in the Upstream Region of the Insulin Receptor Substrate-1 Gene Is Associated with Major Depressive Disorder in the Han Chinese Population.

Fan WangShunying Yu Rubai ZhouRuizhi MaoGuoqing ZhaoXiaoyun GuoQingqing XuJun ChenChen ZhangYi-Ru Fang

Published in: Neuropsychiatric disease and treatment (2020)

The findings imply that the haplotype consisting of rs13411764 and rs3820926 in the upstream of IRS-1 is a risk factor for MDD. This haplotype could affect IRS-1 expression levels, and it is mostly inherited from parents. Thus, the presence of variants in the upstream region of IRS-1 is a risk factor of MDD, and this study could serve as a convincing reference for further studies.

Keyphrases

major depressive disorder
copy number
bipolar disorder
risk factors
poor prognosis
type diabetes
binding protein
genome wide
dna methylation
gene expression
glycemic control
long non coding rna
insulin resistance
case control
genome wide analysis