An Overview of the Mechanism behind Excessive Volume of Pericardial Fat in Heart Failure.
Ki Woon KangSandeep KarnaPublished in: Journal of obesity & metabolic syndrome (2023)
Heart failure (HF) is a clinical syndrome characterized by myocardial dysfunction leading to inefficient blood filling or ejection. Regardless of the etiology, various mechanisms, including adipokine hypersecretion, proinflammatory cytokines, stem cell proliferation, oxidative stress, hyperglycemic toxicity, and autonomic nervous system dysregulation in the pericardial fat (PCF), contribute to the development of HF. PCF has been directly associated with cardiovascular disease, and an increased PCF volume is associated with HF. The PCF acts as neuroendocrine tissue that is closely linked to myocardial function and acts as an energy reservoir. This review aims to summarize each mechanism associated with PCF in HF.
Keyphrases
- acute heart failure
- heart failure
- oxidative stress
- left ventricular
- cardiovascular disease
- cell proliferation
- adipose tissue
- cardiac resynchronization therapy
- dna damage
- atrial fibrillation
- cell cycle
- fatty acid
- metabolic syndrome
- signaling pathway
- induced apoptosis
- pi k akt
- endoplasmic reticulum stress
- heat shock protein