Multiphoton Phosphorescence Quenching Microscopy Reveals Kinetics of Tumor Oxygenation during Antiangiogenesis and Angiotensin Signaling Inhibition.
John D MartinRyan M LanningVikash P ChauhanMargaret R MartinAhmed S MousaWalid S KamounHee-Sun HanHang LeeTriantafyllos StylianopoulosMoungi G BawendiDan G DudaEdward B BrownTimothy P PaderaDai FukumuraRakesh K JainPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
High-resolution spatial and temporal responses of tumor vessels to two agents known to improve vascular perfusion globally reveal spatially heterogeneous changes in vessel structure and function. These dynamic vascular changes should be considered in optimizing the dose and schedule of vascular and stromal normalizing strategies to improve the therapeutic outcome.