Rakesh K Jain (Rakesh Jain)

ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 80

Top Topics

Liver Metastases

Top Venues

Proceedings of the National Academy of Sciences of the United States of America

Cancer immunology research

Clinical cancer research : an official journal of the American Association for Cancer Research

PLoS computational biology

This page only lists publications with an associated author ORCID identifier.

Publications

Jiang Chen, Zohreh Amoozgar, Xin Liu, Shuichi Aoki, Ze-Long Liu, Sarah M Shin, Aya Matsui, Alexei Hernandez, Zhangya Pu, Stefan Halvorsen, Pin-Ji Lei, Meenal Datta, Lingling Zhu, Zhi-Ping Ruan, Lei Shi, Daniel Staiculescu, Koetsu Inoue, Lance L Munn, Dai Fukumura, Peigen Huang, Slim Sassi, Nabeel El-Bardeesy, Won Jin Ho, Rakesh K Jain, Dan G Duda
Reprogramming the Intrahepatic Cholangiocarcinoma Immune Microenvironment by Chemotherapy and CTLA-4 Blockade Enhances Anti-PD1 Therapy. Cancer immunology research (2024)
Meenal Datta, Laura E Via, Veronique Anne Dartois, Danielle M Weiner, Matthew Zimmerman, Firat Kaya, April M Walker, Joel D Fleegle, Isaac D Raplee, Colton McNinch, Maksym Zarodniuk, Walid S Kamoun, Changli Yue, Ashwin Srinivasan Kumar, Sonu Subudhi, Lei Xu, Clifton Earl Barry, Rakesh K Jain
Normalizing granuloma vasculature and matrix improves drug delivery and reduces bacterial burden in tuberculosis-infected rabbits. Proceedings of the National Academy of Sciences of the United States of America 121 (14) (2024)
Jiang Chen, Zohreh Amoozgar, Xin Liu, Shuichi Aoki, Ze-Long Liu, Sarah M Shin, Aya Matsui, Alexei Hernandez, Zhangya Pu, Stefan Halvorsen, Pin-Ji Lei, Meenal Datta, Lingling Zhu, Zhi-Ping Ruan, Lei Shi, Daniel Staiculescu, Koetsu Inoue, Lance L Munn, Dai Fukumura, Peigen Huang, Slim Sassi, Nabeel El-Bardeesy, Won Jin Ho, Rakesh K Jain, Dan G Duda
Reprogramming the Intrahepatic Cholangiocarcinoma Immune Microenvironment by Chemotherapy and CTLA-4 Blockade Enhances Anti-PD-1 Therapy. Cancer immunology research 12 (4) (2024)
Jiang Chen, Zohreh Amoozgar, Xin Liu, Shuichi Aoki, Ze-Long Liu, Sarah M Shin, Aya Matsui, Alexei Hernandez, Zhangya Pu, Stefan Halvorsen, Pin-Ji Lei, Meenal Datta, Lingling Zhu, Zhi-Ping Ruan, Lei Shi, Daniel Staiculescu, Koetsu Inoue, Lance L Munn, Dai Fukumura, Peigen Huang, Slim Sassi, Nabeel El-Bardeesy, Won Jin Ho, Rakesh K Jain, Dan G Duda
Reprogramming the Intrahepatic Cholangiocarcinoma Immune Microenvironment by Chemotherapy and CTLA-4 Blockade Enhances Anti-PD1 Therapy. Cancer immunology research (2024)
Meenal Datta, McCarthy Kennedy, Saeed Siri, Laura E Via, James W Baish, Lei Xu, Veronique Dartois, Clifton E Barry, Rakesh K Jain
Mathematical model of oxygen, nutrient, and drug transport in Tuberculosis Granulomas. PLoS computational biology 20 (2) (2024)
Jiang Chen, Zohreh Amoozgar, Xin Liu, Shuichi Aoki, Ze-Long Liu, Sarah M Shin, Aya Matsui, Alexei Hernandez, Zhangya Pu, Stefan Halvorsen, Pin-Ji Lei, Meenal Datta, Lingling Zhu, Zhi-Ping Ruan, Lei Shi, Daniel Staiculescu, Koetsu Inoue, Lance L Munn, Dai Fukumura, Peigen Huang, Slim Sassi, Nabeel El-Bardeesy, Won Jin Ho, Rakesh K Jain, Dan G Duda
Reprogramming the Intrahepatic Cholangiocarcinoma Immune Microenvironment by Chemotherapy and CTLA-4 Blockade Enhances Anti-PD1 Therapy. Cancer immunology research (2024)
Meenal Datta, Laura E Via, Veronique Anne Dartois, Danielle M Weiner, Matthew Zimmerman, Firat Kaya, April M Walker, Joel D Fleegle, Isaac D Raplee, Colton McNinch, Maksym Zarodniuk, Walid S Kamoun, Changli Yue, Ashwin Srinivasan Kumar, Sonu Subudhi, Lei Xu, Clifton Earl Barry, Rakesh K Jain
Normalizing granuloma vasculature and matrix improves drug delivery and reduces bacterial burden in tuberculosis-infected rabbits. Proceedings of the National Academy of Sciences of the United States of America 121 (14) (2024)
Jiang Chen, Zohreh Amoozgar, Xin Liu, Shuichi Aoki, Ze-Long Liu, Sarah M Shin, Aya Matsui, Alexei Hernandez, Zhangya Pu, Stefan Halvorsen, Pin-Ji Lei, Meenal Datta, Lingling Zhu, Zhi-Ping Ruan, Lei Shi, Daniel Staiculescu, Koetsu Inoue, Lance L Munn, Dai Fukumura, Peigen Huang, Slim Sassi, Nabeel El-Bardeesy, Won Jin Ho, Rakesh K Jain, Dan G Duda
Reprogramming the Intrahepatic Cholangiocarcinoma Immune Microenvironment by Chemotherapy and CTLA-4 Blockade Enhances Anti-PD1 Therapy. Cancer immunology research (2024)
Meenal Datta, Laura E Via, Veronique Anne Dartois, Danielle M Weiner, Matthew Zimmerman, Firat Kaya, April M Walker, Joel D Fleegle, Isaac D Raplee, Colton McNinch, Maksym Zarodniuk, Walid S Kamoun, Changli Yue, Ashwin Srinivasan Kumar, Sonu Subudhi, Lei Xu, Clifton Earl Barry, Rakesh K Jain
Normalizing granuloma vasculature and matrix improves drug delivery and reduces bacterial burden in tuberculosis-infected rabbits. Proceedings of the National Academy of Sciences of the United States of America 121 (14) (2024)
Meenal Datta, Laura E Via, Veronique Anne Dartois, Danielle M Weiner, Matthew Zimmerman, Firat Kaya, April M Walker, Joel D Fleegle, Isaac D Raplee, Colton McNinch, Maksym Zarodniuk, Walid S Kamoun, Changli Yue, Ashwin Srinivasan Kumar, Sonu Subudhi, Lei Xu, Clifton Earl Barry, Rakesh K Jain
Normalizing granuloma vasculature and matrix improves drug delivery and reduces bacterial burden in tuberculosis-infected rabbits. Proceedings of the National Academy of Sciences of the United States of America 121 (14) (2024)
Jiang Chen, Zohreh Amoozgar, Xin Liu, Shuichi Aoki, Ze-Long Liu, Sarah M Shin, Aya Matsui, Alexei Hernandez, Zhangya Pu, Stefan Halvorsen, Pin-Ji Lei, Meenal Datta, Lingling Zhu, Zhi-Ping Ruan, Lei Shi, Daniel Staiculescu, Koetsu Inoue, Lance L Munn, Dai Fukumura, Peigen Huang, Slim Sassi, Nabeel El-Bardeesy, Won Jin Ho, Rakesh K Jain, Dan G Duda
Reprogramming the Intrahepatic Cholangiocarcinoma Immune Microenvironment by Chemotherapy and CTLA-4 Blockade Enhances Anti-PD1 Therapy. Cancer immunology research (2024)
Meenal Datta, McCarthy Kennedy, Saeed Siri, Laura E Via, James W Baish, Lei Xu, Véronique Dartois, Clifton E Barry, Rakesh K Jain
Mathematical model of oxygen, nutrient, and drug transport in tuberculosis granulomas. PLoS computational biology 20 (2) (2024)
Meenal Datta, McCarthy Kennedy, Saeed Siri, Laura E Via, James W Baish, Lei Xu, Véronique Dartois, Clifton E Barry, Rakesh K Jain
Mathematical model of oxygen, nutrient, and drug transport in tuberculosis granulomas. PLoS computational biology 20 (2) (2024)
Jiang Chen, Zohreh Amoozgar, Xin Liu, Shuichi Aoki, Ze-Long Liu, Sarah M Shin, Aya Matsui, Alexei Hernandez, Zhangya Pu, Stefan Halvorsen, Pin-Ji Lei, Meenal Datta, Lingling Zhu, Zhi-Ping Ruan, Lei Shi, Daniel Staiculescu, Koetsu Inoue, Lance L Munn, Dai Fukumura, Peigen Huang, Slim Sassi, Nabeel El-Bardeesy, Won Jin Ho, Rakesh K Jain, Dan G Duda
Reprogramming the Intrahepatic Cholangiocarcinoma Immune Microenvironment by Chemotherapy and CTLA-4 Blockade Enhances Anti-PD-1 Therapy. Cancer immunology research 12 (4) (2024)
Jiang Chen, Zohreh Amoozgar, Xin Liu, Shuichi Aoki, Ze-Long Liu, Sarah M Shin, Aya Matsui, Alexei Hernandez, Zhangya Pu, Stefan Halvorsen, Pin-Ji Lei, Meenal Datta, Lingling Zhu, Zhi-Ping Ruan, Lei Shi, Daniel Staiculescu, Koetsu Inoue, Lance L Munn, Dai Fukumura, Peigen Huang, Slim Sassi, Nabeel El-Bardeesy, Won Jin Ho, Rakesh K Jain, Dan G Duda
Reprogramming the Intrahepatic Cholangiocarcinoma Immune Microenvironment by Chemotherapy and CTLA-4 Blockade Enhances Anti-PD-1 Therapy. Cancer immunology research 12 (4) (2024)
Jiang Chen, Zohreh Amoozgar, Xin Liu, Shuichi Aoki, Ze-Long Liu, Sarah M Shin, Aya Matsui, Alexei Hernandez, Zhangya Pu, Stefan Halvorsen, Pin-Ji Lei, Meenal Datta, Lingling Zhu, Zhi-Ping Ruan, Lei Shi, Daniel Staiculescu, Koetsu Inoue, Lance L Munn, Dai Fukumura, Peigen Huang, Slim Sassi, Nabeel El-Bardeesy, Won Jin Ho, Rakesh K Jain, Dan G Duda
Reprogramming the Intrahepatic Cholangiocarcinoma Immune Microenvironment by Chemotherapy and CTLA-4 Blockade Enhances Anti-PD1 Therapy. Cancer immunology research (2024)
Meenal Datta, McCarthy Kennedy, Saeed Siri, Laura E Via, James W Baish, Lei Xu, Véronique Dartois, Clifton E Barry, Rakesh K Jain
Mathematical model of oxygen, nutrient, and drug transport in tuberculosis granulomas. PLoS computational biology 20 (2) (2024)
Yves Boucher, Jessica M Posada, Sonu Subudhi, Ashwin Srinivasan Kumar, Spencer R Rosario, Liqun Gu, Heena Kumra, Mari A Mino-Kenudson, Nilesh P Talele, Dan G Duda, Dai Fukumura, Jennifer Y Wo, Jeffrey W Clark, David P Ryan, Carlos F Fernandez-Del Castillo, Theodore S Hong, Mikaël J Pittet, Rakesh K Jain
Addition of losartan to FOLFIRINOX and chemoradiation reduces immunosuppression-associated genes, Tregs and FOXP3+ cancer cells in locally advanced pancreatic cancer. Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Rakesh K Jain, Shanmugarajan Krishnan, Noo Li Jeon, Zohreh Amoozgar, Sonu Subudhi, Ashwin Kumar, Jessica Posada, Neal Lindeman, Pinji Lei, Mark Duquette, Sylvie Roberge, Peigen Huang, Patrik Andersson, Meenal Datta, Lance L Munn, Dai Fukumura
Wnt inhibition alleviates resistance to immune checkpoint blockade in glioblastoma. Research square (2023)
Xinyue Dong, Jun Ren, Zohreh Amoozgar, Noo Li Jeon, Meenal Datta, Sylvie Roberge, Mark Duquette, Dai Fukumura, Rakesh K Jain
Anti-VEGF therapy improves EGFR-vIII-CAR-T cell delivery and efficacy in syngeneic glioblastoma models in mice. Journal for immunotherapy of cancer 11 (3) (2023)
Rakesh K Jain, Shanmugarajan Krishnan, Noo Li Jeon, Zohreh Amoozgar, Sonu Subudhi, Ashwin Kumar, Jessica Posada, Neal Lindeman, Pinji Lei, Mark Duquette, Sylvie Roberge, Peigen Huang, Patrik Andersson, Meenal Datta, Lance L Munn, Dai Fukumura
Wnt inhibition alleviates resistance to immune checkpoint blockade in glioblastoma. Research square (2023)
Chrysovalantis Voutouri, C Corey Hardin, Vivek Naranbhai, Mohammad R Nikmaneshi, Melin J Khandekar, Justin F Gainor, Triantafyllos Stylianopoulos, Lance L Munn, Rakesh K Jain
Mechanistic model for booster doses effectiveness in healthy, cancer, and immunosuppressed patients infected with SARS-CoV-2. Proceedings of the National Academy of Sciences of the United States of America 120 (3) (2023)
Meenal Datta, Sampurna Chatterjee, Elizabeth M Perez, Simon Gritsch, Sylvie Roberge, Mark Duquette, Ivy X Chen, Kamila Naxerova, Ashwin Srinivasan Kumar, Mitrajit Ghosh, Kyrre E Emblem, Mei R Ng, William W Ho, Pragya Kumar, Shanmugarajan Krishnan, Xinyue Dong, Maria C Speranza, Martha R Neagu, J Bryan Iorgulescu, Raymond Y Huang, Gilbert Youssef, David A Reardon, Arlene H Sharpe, Gordon J Freeman, Mario L Suvà, Lei Xu, Rakesh K Jain
Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma mouse models. Proceedings of the National Academy of Sciences of the United States of America 120 (6) (2023)
Xinyue Dong, Jun Ren, Zohreh Amoozgar, Noo Li Jeon, Meenal Datta, Sylvie Roberge, Mark Duquette, Dai Fukumura, Rakesh K Jain
Anti-VEGF therapy improves EGFR-vIII-CAR-T cell delivery and efficacy in syngeneic glioblastoma models in mice. Journal for immunotherapy of cancer 11 (3) (2023)
Meenal Datta, Sampurna Chatterjee, Elizabeth M Perez, Simon Gritsch, Sylvie Roberge, Mark Duquette, Ivy X Chen, Kamila Naxerova, Ashwin Srinivasan Kumar, Mitrajit Ghosh, Kyrre E Emblem, Mei R Ng, William W Ho, Pragya Kumar, Shanmugarajan Krishnan, Xinyue Dong, Maria C Speranza, Martha R Neagu, J Bryan Iorgulescu, Raymond Y Huang, Gilbert Youssef, David A Reardon, Arlene H Sharpe, Gordon J Freeman, Mario L Suvà, Lei Xu, Rakesh K Jain
Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma mouse models. Proceedings of the National Academy of Sciences of the United States of America 120 (6) (2023)
Meenal Datta, Sampurna Chatterjee, Elizabeth M Perez, Simon Gritsch, Sylvie Roberge, Mark Duquette, Ivy X Chen, Kamila Naxerova, Ashwin Srinivasan Kumar, Mitrajit Ghosh, Kyrre E Emblem, Mei R Ng, William W Ho, Pragya Kumar, Shanmugarajan Krishnan, Xinyue Dong, Maria C Speranza, Martha R Neagu, J Bryan Iorgulescu, Raymond Y Huang, Gilbert Youssef, David A Reardon, Arlene H Sharpe, Gordon J Freeman, Mario L Suvà, Lei Xu, Rakesh K Jain
Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma mouse models. Proceedings of the National Academy of Sciences of the United States of America 120 (6) (2023)
Rakesh K Jain, Shanmugarajan Krishnan, Noo Li Jeon, Zohreh Amoozgar, Sonu Subudhi, Ashwin Kumar, Jessica Posada, Neal Lindeman, Pinji Lei, Mark Duquette, Sylvie Roberge, Peigen Huang, Patrik Andersson, Meenal Datta, Lance L Munn, Dai Fukumura
Wnt inhibition alleviates resistance to immune checkpoint blockade in glioblastoma. Research square (2023)
Jiang Chen, Zohreh Amoozgar, Xin Liu, Shuichi Aoki, Zelong Liu, Sarah Shin, Aya Matsui, Zhangya Pu, Pin-Ji Lei, Meenal Datta, Lingling Zhu, Zhiping Ruan, Lei Shi, Daniel Staiculescu, Koetsu Inoue, Lance L Munn, Dai Fukumura, Peigen Huang, Nabeel Bardeesy, Won Jin Ho, Rakesh K Jain, Dan G Duda
Reprogramming Intrahepatic Cholangiocarcinoma Immune Microenvironment by Chemotherapy and CTLA-4 Blockade Enhances Anti-PD1 Therapy. bioRxiv : the preprint server for biology (2023)
Meenal Datta, Sampurna Chatterjee, Elizabeth M Perez, Simon Gritsch, Sylvie Roberge, Mark Duquette, Ivy X Chen, Kamila Naxerova, Ashwin Srinivasan Kumar, Mitrajit Ghosh, Kyrre E Emblem, Mei R Ng, William W Ho, Pragya Kumar, Shanmugarajan Krishnan, Xinyue Dong, Maria C Speranza, Martha R Neagu, J Bryan Iorgulescu, Raymond Y Huang, Gilbert Youssef, David A Reardon, Arlene H Sharpe, Gordon J Freeman, Mario L Suvà, Lei Xu, Rakesh K Jain
Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma mouse models. Proceedings of the National Academy of Sciences of the United States of America 120 (6) (2023)
Chrysovalantis Voutouri, C Corey Hardin, Vivek Naranbhai, Mohammad R Nikmaneshi, Melin J Khandekar, Justin F Gainor, Triantafyllos Stylianopoulos, Lance L Munn, Rakesh K Jain
Mechanistic model for booster doses effectiveness in healthy, cancer, and immunosuppressed patients infected with SARS-CoV-2. Proceedings of the National Academy of Sciences of the United States of America 120 (3) (2023)
Chrysovalantis Voutouri, C Corey Hardin, Vivek Naranbhai, Mohammad R Nikmaneshi, Melin J Khandekar, Justin F Gainor, Triantafyllos Stylianopoulos, Lance L Munn, Rakesh K Jain
Mechanistic model for booster doses effectiveness in healthy, cancer, and immunosuppressed patients infected with SARS-CoV-2. Proceedings of the National Academy of Sciences of the United States of America 120 (3) (2023)
Chrysovalantis Voutouri, C Corey Hardin, Vivek Naranbhai, Mohammad R Nikmaneshi, Melin J Khandekar, Justin F Gainor, Triantafyllos Stylianopoulos, Lance L Munn, Rakesh K Jain
Mechanistic model for booster doses effectiveness in healthy, cancer, and immunosuppressed patients infected with SARS-CoV-2. Proceedings of the National Academy of Sciences of the United States of America 120 (3) (2023)
Jiang Chen, Zohreh Amoozgar, Xin Liu, Shuichi Aoki, Zelong Liu, Sarah Shin, Aya Matsui, Zhangya Pu, Pin-Ji Lei, Meenal Datta, Lingling Zhu, Zhiping Ruan, Lei Shi, Daniel Staiculescu, Koetsu Inoue, Lance L Munn, Dai Fukumura, Peigen Huang, Nabeel Bardeesy, Won Jin Ho, Rakesh K Jain, Dan G Duda
Reprogramming Intrahepatic Cholangiocarcinoma Immune Microenvironment by Chemotherapy and CTLA-4 Blockade Enhances Anti-PD1 Therapy. bioRxiv : the preprint server for biology (2023)
Meenal Datta, Sampurna Chatterjee, Elizabeth M Perez, Simon Gritsch, Sylvie Roberge, Mark Duquette, Ivy X Chen, Kamila Naxerova, Ashwin Srinivasan Kumar, Mitrajit Ghosh, Kyrre E Emblem, Mei R Ng, William W Ho, Pragya Kumar, Shanmugarajan Krishnan, Xinyue Dong, Maria C Speranza, Martha R Neagu, J Bryan Iorgulescu, Raymond Y Huang, Gilbert Youssef, David A Reardon, Arlene H Sharpe, Gordon J Freeman, Mario L Suvà, Lei Xu, Rakesh K Jain
Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma mouse models. Proceedings of the National Academy of Sciences of the United States of America 120 (6) (2023)
Meenal Datta, Sampurna Chatterjee, Elizabeth M Perez, Simon Gritsch, Sylvie Roberge, Mark Duquette, Ivy X Chen, Kamila Naxerova, Ashwin Srinivasan Kumar, Mitrajit Ghosh, Kyrre E Emblem, Mei R Ng, William W Ho, Pragya Kumar, Shanmugarajan Krishnan, Xinyue Dong, Maria C Speranza, Martha R Neagu, J Bryan Iorgulescu, Raymond Y Huang, Gilbert Youssef, David A Reardon, Arlene H Sharpe, Gordon J Freeman, Mario L Suvà, Lei Xu, Rakesh K Jain
Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma mouse models. Proceedings of the National Academy of Sciences of the United States of America 120 (6) (2023)
Chrysovalantis Voutouri, C Corey Hardin, Vivek Naranbhai, Mohammad R Nikmaneshi, Melin J Khandekar, Justin F Gainor, Triantafyllos Stylianopoulos, Lance L Munn, Rakesh K Jain
Mechanistic model for booster doses effectiveness in healthy, cancer, and immunosuppressed patients infected with SARS-CoV-2. Proceedings of the National Academy of Sciences of the United States of America 120 (3) (2023)
Rakesh K Jain, Shanmugarajan Krishnan, Noo Li Jeon, Zohreh Amoozgar, Sonu Subudhi, Ashwin Kumar, Jessica Posada, Neal Lindeman, Pinji Lei, Mark Duquette, Sylvie Roberge, Peigen Huang, Patrik Andersson, Meenal Datta, Lance L Munn, Dai Fukumura
Wnt inhibition alleviates resistance to immune checkpoint blockade in glioblastoma. Research square (2023)
Meenal Datta, Sampurna Chatterjee, Elizabeth M Perez, Simon Gritsch, Sylvie Roberge, Mark Duquette, Ivy X Chen, Kamila Naxerova, Ashwin Srinivasan Kumar, Mitrajit Ghosh, Kyrre E Emblem, Mei R Ng, William W Ho, Pragya Kumar, Shanmugarajan Krishnan, Xinyue Dong, Maria C Speranza, Martha R Neagu, J Bryan Iorgulescu, Raymond Y Huang, Gilbert Youssef, David A Reardon, Arlene H Sharpe, Gordon J Freeman, Mario L Suvà, Lei Xu, Rakesh K Jain
Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma mouse models. Proceedings of the National Academy of Sciences of the United States of America 120 (6) (2023)
Chrysovalantis Voutouri, C Corey Hardin, Vivek Naranbhai, Mohammad R Nikmaneshi, Melin J Khandekar, Justin F Gainor, Triantafyllos Stylianopoulos, Lance L Munn, Rakesh K Jain
Mechanistic model for booster doses effectiveness in healthy, cancer, and immunosuppressed patients infected with SARS-CoV-2. Proceedings of the National Academy of Sciences of the United States of America 120 (3) (2023)
Chrysovalantis Voutouri, C Corey Hardin, Vivek Naranbhai, Mohammad R Nikmaneshi, Melin J Khandekar, Justin F Gainor, Triantafyllos Stylianopoulos, Lance L Munn, Rakesh K Jain
Mechanistic model for booster doses effectiveness in healthy, cancer, and immunosuppressed patients infected with SARS-CoV-2. Proceedings of the National Academy of Sciences of the United States of America 120 (3) (2023)
Yves Boucher, Jessica M Posada, Sonu Subudhi, Ashwin Srinivasan Kumar, Spencer R Rosario, Liqun Gu, Heena Kumra, Mari A Mino-Kenudson, Nilesh P Talele, Dan G Duda, Dai Fukumura, Jennifer Y Wo, Jeffrey W Clark, David P Ryan, Carlos F Fernandez-Del Castillo, Theodore S Hong, Mikaël J Pittet, Rakesh K Jain
Addition of losartan to FOLFIRINOX and chemoradiation reduces immunosuppression-associated genes, Tregs and FOXP3+ cancer cells in locally advanced pancreatic cancer. Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Meenal Datta, Sampurna Chatterjee, Elizabeth M Perez, Simon Gritsch, Sylvie Roberge, Mark Duquette, Ivy X Chen, Kamila Naxerova, Ashwin Srinivasan Kumar, Mitrajit Ghosh, Kyrre E Emblem, Mei R Ng, William W Ho, Pragya Kumar, Shanmugarajan Krishnan, Xinyue Dong, Maria C Speranza, Martha R Neagu, J Bryan Iorgulescu, Raymond Y Huang, Gilbert Youssef, David A Reardon, Arlene H Sharpe, Gordon J Freeman, Mario L Suvà, Lei Xu, Rakesh K Jain
Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma mouse models. Proceedings of the National Academy of Sciences of the United States of America 120 (6) (2023)
Yves Boucher, Jessica M Posada, Sonu Subudhi, Ashwin Srinivasan Kumar, Spencer R Rosario, Liqun Gu, Heena Kumra, Mari A Mino-Kenudson, Nilesh P Talele, Dan G Duda, Dai Fukumura, Jennifer Y Wo, Jeffrey W Clark, David P Ryan, Carlos F Fernandez-Del Castillo, Theodore S Hong, Mikaël J Pittet, Rakesh K Jain
Addition of losartan to FOLFIRINOX and chemoradiation reduces immunosuppression-associated genes, Tregs and FOXP3+ cancer cells in locally advanced pancreatic cancer. Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Dan G Duda, Rakesh K Jain
Revisiting Antiangiogenic Multikinase Inhibitors in the Era of Immune Checkpoint Blockade: The Case of Sorafenib. Cancer research 82 (20) (2022)
William L Hwang, Karthik A Jagadeesh, Jimmy A Guo, Hannah I Hoffman, Payman Yadollahpour, Jason W Reeves, Rahul Mohan, Eugene Drokhlyansky, Nicholas Van Wittenberghe, Orr Ashenberg, Samouil L Farhi, Denis Schapiro, Prajan Divakar, Eric M Miller, Daniel R Zollinger, George Eng, Jason M Schenkel, Jennifer Su, Carina Shiau, Patrick Yu, William A Freed-Pastor, Domenic Abbondanza, Arnav Mehta, Joshua Gould, Conner Lambden, Caroline B M Porter, Alexander Tsankov, Danielle Dionne, Julia Waldman, Michael S Cuoco, Lan Nguyen, Toni Marie Delorey, Devan Phillips, Jaimie L Barth, Marina Kem, Clifton Rodrigues, Debora Ciprani, Jorge Roldan, Piotr Zelga, Vjola Jorgji, Jonathan H Chen, Zackery Ely, Daniel Zhao, Kit Fuhrman, Robin Fropf, Joseph M Beechem, Jay S Loeffler, David P Ryan, Colin D Weekes, Cristina R Ferrone, Motaz Qadan, Martin J Aryee, Rakesh K Jain, Donna S Neuberg, Jennifer Y Wo, Theodore S Hong, Ramnik Xavier, Andrew J Aguirre, Orit Rozenblatt-Rosen, Mari A Mino-Kenudson, Carlos Fernandez-Del Castillo, Andrew S Liss, David Tsai Ting, Tyler Jacks, Aviv Regev
Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment. Nature genetics 54 (8) (2022)
John D Martin, Ryan M Lanning, Vikash P Chauhan, Margaret R Martin, Ahmed S Mousa, Walid S Kamoun, Hee-Sun Han, Hang Lee, Triantafyllos Stylianopoulos, Moungi G Bawendi, Dan G Duda, Edward B Brown, Timothy P Padera, Dai Fukumura, Rakesh K Jain
Multiphoton Phosphorescence Quenching Microscopy Reveals Kinetics of Tumor Oxygenation during Antiangiogenesis and Angiotensin Signaling Inhibition. Clinical cancer research : an official journal of the American Association for Cancer Research 28 (14) (2022)
Sonia A Patel, Monique B Nilsson, Xiuning Li, Cascone Tina, Rakesh K Jain, John Victor Heymach
Molecular Mechanisms and Future Implications of VEGF/VEGFR in Cancer Therapy. Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
Giselle L Saulnier Sholler, Dan G Duda, Genevieve Bergendahl, David Ebb, Matija Snuderl, Theodore W Laetsch, Jennifer Michlitsch, Derek Hanson, Michael S Isakoff, Kevin Bielamowicz, Jacqueline M Kraveka, William S Ferguson, Peter Carmeliet, A De Deene, Lore Gijsen, Rakesh K Jain
A Phase I Trial of TB-403 in Relapsed Medulloblastoma, Neuroblastoma, Ewing Sarcoma, and Alveolar Rhabdomyosarcoma. Clinical cancer research : an official journal of the American Association for Cancer Research 28 (18) (2022)
Marie Siwicki, Nicolas A Gort-Freitas, Marius Messemaker, Ruben Bill, Jeremy Gungabeesoon, Camilla Engblom, Rapolas Zilionis, Christopher Garris, Genevieve M Gerhard, Anna Kohl, Yunkang Lin, Angela E Zou, Chiara Cianciaruso, Evangelia Bolli, Christina Pfirschke, Yi-Jang Lin, Cécile Piot, John E Mindur, Nilesh P Talele, Rainer H Kohler, Yoshiko Iwamoto, Mari A Mino-Kenudson, Sara I Pai, Claudio deVito, Thibaud Koessler, Doron Merkler, Alexander Coukos, Alexandre Wicky, Montserrat Fraga, Christine Sempoux, Rakesh K Jain, Pierre-Yves Dietrich, Olivier Michielin, Ralph Weissleder, Allon M Klein, Mikaël J Pittet
Resident Kupffer cells and neutrophils drive liver toxicity in cancer immunotherapy. Science immunology 6 (61) (2022)
Zohreh Amoozgar, Jonas Kloepper, Jun Ren, Rong En Tay, Samuel W Kazer, Evgeny Kiner, Shanmugarajan Krishnan, Jessica M Posada, Mitrajit Ghosh, Emilie Mamessier, Christina Wong, Gino B Ferraro, Ana Batista, Nancy Wang, Mark Badeaux, Sylvie Roberge, Lei Xu, Peigen Huang, Alex K Shalek, Dai Fukumura, Hye-Jung Kim, Rakesh K Jain
Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas. Nature communications 12 (1) (2021)
Lance L Munn, Triantafyllos Stylianopoulos, Natalie K Jain, C Corey Hardin, Melin J Khandekar, Rakesh K Jain
Vascular Normalization to Improve Treatment of COVID-19: Lessons from Treatment of Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 27 (10) (2021)
Chrysovalantis Voutouri, Mohammad Reza Nikmaneshi, C Corey Hardin, Ankit B Patel, Ashish Verma, Melin J Khandekar, Sayon Dutta, Triantafyllos Stylianopoulos, Lance L Munn, Rakesh K Jain
In silico dynamics of COVID-19 phenotypes for optimizing clinical management. Proceedings of the National Academy of Sciences of the United States of America 118 (3) (2021)
Sonu Subudhi, Ashish Verma, Ankit B Patel, C Corey Hardin, Melin J Khandekar, Hang Lee, Dustin S McEvoy, Triantafyllos Stylianopoulos, Lance L Munn, Sayon Dutta, Rakesh K Jain
Comparing machine learning algorithms for predicting ICU admission and mortality in COVID-19. NPJ digital medicine 4 (1) (2021)
Shanmugarajan Krishnan, Zohreh Amoozgar, Dai Fukumura, Rakesh K Jain
Implications of a granulocyte-high glioblastoma microenvironment in immune suppression and therapy resistance†. The Journal of pathology 254 (2) (2021)
Limeng Wu, Sasa Vasilijic, Yao Sun, Jie Chen, Lukas David Landegger, Yanling Zhang, Wenjianlong Zhou, Jun Ren, Samuel Early, Zhenzhen Yin, William W Ho, Na Zhang, Xing Gao, Grace Y Lee, Meenal Datta, Jessica E Sagers, Alyssa Brown, Alona Muzikansky, Anat O Stemmer-Rachamimov, Luo Zhang, Scott R Plotkin, Rakesh K Jain, Konstantina M Stankovic, Lei Xu
Losartan prevents tumor-induced hearing loss and augments radiation efficacy in NF2 schwannoma rodent models. Science translational medicine 13 (602) (2021)
Igor L Gomes-Santos, Zohreh Amoozgar, Ashwin Srinivasan Kumar, William W Ho, Kangsan Roh, Nilesh P Talele, Hannah Curtis, Kosuke Kawaguchi, Rakesh K Jain, Dai Fukumura
Exercise Training Improves Tumor Control by Increasing CD8+ T-cell Infiltration via CXCR3 Signaling and Sensitizes Breast Cancer to Immune Checkpoint Blockade. Cancer immunology research 9 (7) (2021)
William W Ho, Igor L Gomes-Santos, Shuichi Aoki, Meenal Datta, Kosuke Kawaguchi, Nilesh P Talele, Sylvie Roberge, Jun Ren, Hao Liu, Ivy X Chen, Patrik Andersson, Sampurna Chatterjee, Ashwin Srinivasan Kumar, Zohreh Amoozgar, Qixian Zhang, Peigen Huang, Mei Rosa Ng, Vikash P Chauhan, Lei Xu, Dan G Duda, Jeffrey W Clark, Mikael J Pittet, Dai Fukumura, Rakesh K Jain
Dendritic cell paucity in mismatch repair-proficient colorectal cancer liver metastases limits immune checkpoint blockade efficacy. Proceedings of the National Academy of Sciences of the United States of America 118 (45) (2021)
Yves Boucher, Ashwin Srinivasan Kumar, Jessica M Posada, Evisa Gjini, Kathleen Pfaff, Mikel Lipschitz, Ana Lako, Dan G Duda, Scott J Rodig, F Stephen Hodi, Rakesh K Jain
Bevacizumab improves tumor infiltration of mature dendritic cells and effector T-cells in triple-negative breast cancer patients. NPJ precision oncology 5 (1) (2021)
Ivy X Chen, Kathleen Newcomer, Kristen E Pauken, Vikram R Juneja, Kamila Naxerova, Michelle W Wu, Matthias Pinter, Debattama R Sen, Meromit Singer, Arlene H Sharpe, Rakesh K Jain
A bilateral tumor model identifies transcriptional programs associated with patient response to immune checkpoint blockade. Proceedings of the National Academy of Sciences of the United States of America 117 (38) (2020)
Hadi T Nia, Lance L Munn, Rakesh K Jain
Physical traits of cancer. Science (New York, N.Y.) 370 (6516) (2020)
Mari Saif, Wilhelmus Josephus Kwanten, Jessica A Carr, Ivy X Chen, Jessica M Posada, Amitabh Srivastava, Juanye Zhang, Yi Zheng, Matthias Pinter, Sampurna Chatterjee, Samir Softic, C Ronald Kahn, Klaus van Leyen, Oliver T Bruns, Rakesh K Jain, Moungi G Bawendi
Non-invasive monitoring of chronic liver disease via near-infrared and shortwave-infrared imaging of endogenous lipofuscin. Nature biomedical engineering 4 (8) (2020)
Lakshmi Nayak, Annette M Molinaro, Katherine Peters, Jennifer L Clarke, Justin T Jordan, John de Groot, Leia Nghiemphu, Thomas Kaley, Howard Colman, Christine McCluskey, Sarah Gaffey, Timothy R Smith, David J Cote, Mariano Severgnini, Jennifer H Yearley, Qing Zhao, Wendy M Blumenschein, Dan G Duda, Alona Muzikansky, Rakesh K Jain, Patrick Y Wen, David A Reardon
Randomized Phase II and Biomarker Study of Pembrolizumab plus Bevacizumab versus Pembrolizumab Alone for Patients with Recurrent Glioblastoma. Clinical cancer research : an official journal of the American Association for Cancer Research 27 (4) (2020)
Erik Sahai, Igor Astsaturov, Edna Cukierman, David G DeNardo, Mikala Egeblad, Ronald M Evans, Douglas Fearon, Florian R Greten, Sunil R Hingorani, Tony Hunter, Richard O Hynes, Rakesh K Jain, Tobias Janowitz, Claus Jorgensen, Alec C Kimmelman, Mikhail G Kolonin, Robert G Maki, R Scott Powers, Ellen Puré, Daniel C Ramirez, Ruth Scherz-Shouval, Mara H Sherman, Sheila A Stewart, Thea D Tlsty, David A Tuveson, Fiona M Watt, Valerie Weaver, Ashani T Weeraratna, Zena Werb
A framework for advancing our understanding of cancer-associated fibroblasts. Nature reviews. Cancer 20 (3) (2020)
Bryan Ngo, Eugenie Kim, Victoria Osorio-Vasquez, Sophia Doll, Sophia Bustraan, Roger J Liang, Alba Luengo, Shawn M Davidson, Ahmed Ali, Gino B Ferraro, Grant M Fischer, Roozbeh Eskandari, Diane S Kang, Jing Ni, Ariana Plasger, Vinagolu K Rajasekhar, Edward R Kastenhuber, Sarah Bacha, Roshan K Sriram, Benjamin D Stein, Samuel F Bakhoum, Matija Snuderl, Paolo Cotzia, John H Healey, Nello Mainolfi, Vipin Suri, Adam Friedman, Mark Manfredi, David M Sabatini, Drew R Jones, Min Yu, Jean J Zhao, Rakesh K Jain, Kayvan R Keshari, Michael A Davies, Matthew G Vander Heiden, Eva Hernando, Matthias Mann, Lewis C Cantley, Michael E Pacold
Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition. Cancer discovery 10 (9) (2020)
Fotios Mpekris, Chrysovalantis Voutouri, James W Baish, Dan G Duda, Lance L Munn, Triantafyllos Stylianopoulos, Rakesh K Jain
Combining microenvironment normalization strategies to improve cancer immunotherapy. Proceedings of the National Academy of Sciences of the United States of America 117 (7) (2020)
David G Millar, Rakesh R Ramjiawan, Kosuke Kawaguchi, Nisha Gupta, Jiang Chen, Songfa Zhang, Takashi Nojiri, William W Ho, Shuichi Aoki, Keehoon Jung, Ivy Chen, Feng Shi, James M Heather, Kohei Shigeta, Laura T Morton, Sean Sepulveda, Li Wan, Ricky Joseph, Eleanor Minogue, Ashok Khatri, Aditya Bardia, Leif W Ellisen, Ryan B Corcoran, Aaron N Hata, Sara I Pai, Rakesh K Jain, Dai Fukumura, Dan G Duda, Mark Cobbold
Antibody-mediated delivery of viral epitopes to tumors harnesses CMV-specific T cells for cancer therapy. Nature biotechnology 38 (4) (2020)
John D Martin, Horacio Cabral, Triantafyllos Stylianopoulos, Rakesh K Jain
Improving cancer immunotherapy using nanomedicines: progress, opportunities and challenges. Nature reviews. Clinical oncology 17 (4) (2020)
Hadi T Nia, Meenal Datta, Giorgio Seano, Sue Zhang, William W Ho, Sylvie Roberge, Peigen Huang, Lance L Munn, Rakesh K Jain
In vivo compression and imaging in mouse brain to measure the effects of solid stress. Nature protocols 15 (8) (2020)
Xin Jin, Zelalem Demere, Karthik Nair, Ahmed Ali, Gino B Ferraro, Ted Natoli, Amy Deik, Lia Petronio, Andrew A Tang, Cong Zhu, Li Wang, Danny Rosenberg, Vamsi Mangena, Jennifer Roth, Kwanghun Chung, Rakesh K Jain, Andrew T Chan, Matthew G Vander Heiden, Todd R Golub
A metastasis map of human cancer cell lines. Nature 588 (7837) (2020)
Sivan Subburaju, Sarah Kaye, Yong Kee Choi, Jugajyoti Baruah, Debkanya Datta, Jun Ren, Ashwin Srinivasan Kumar, Gabor Szabo, Dai Fukumura, Rakesh K Jain, Abdallah Elkhal, Anju Vasudevan
NAD+-mediated rescue of prenatal forebrain angiogenesis restores postnatal behavior. Science advances 6 (41) (2020)
Manuel Valiente, Amanda E D Van Swearingen, Carey K Anders, Amos Bairoch, Adrienne A Boire, Paula D Bos, Diana M Cittelly, Neta Erez, Gino B Ferraro, Dai Fukumura, Brunilde Gril, Meenhard Herlyn, Sheri L Holmen, Rakesh K Jain, Johanna A Joyce, Mihaela Lorger, Joan Massague, Josh Neman, Nicola R Sibson, Patricia S Steeg, Frits Thorsen, Leonie S Young, Damir Varešlija, Adina Vultur, Frances Weis-Garcia, Frank Winkler
Brain Metastasis Cell Lines Panel: A Public Resource of Organotropic Cell Lines. Cancer research 80 (20) (2020)
Joao Incio, Jennifer A Ligibel, Daniel T McManus, Priya Suboj, Keehoon Jung, Kosuke Kawaguchi, Matthias Pinter, Suboj Babykutty, Shan Min Chin, Trupti D Vardam, Yuhui Huang, Nuh N Rahbari, Sylvie Roberge, Dannie Wang, Igor L Gomes-Santos, Stefan B Puchner, Christopher L Schlett, Udo Hoffmman, Marek Ancukiewicz, Sara M Tolaney, Ian E Krop, Dan G Duda, Yves Boucher, Dai Fukumura, Rakesh K Jain
Obesity promotes resistance to anti-VEGF therapy in breast cancer by up-regulating IL-6 and potentially FGF-2. Science translational medicine 10 (432) (2019)
Costas D Arvanitis, Gino B Ferraro, Rakesh K Jain
The blood-brain barrier and blood-tumour barrier in brain tumours and metastases. Nature reviews. Cancer 20 (1) (2019)
Giorgio Seano, Hadi T Nia, Kyrre E Emblem, Meenal Datta, Jun Ren, Shanmugarajan Krishnan, Jonas Kloepper, Marco C Pinho, William W Ho, Mitrajit Ghosh, Vasileios Askoxylakis, Gino B Ferraro, Lars Riedemann, Elizabeth R Gerstner, Tracy T Batchelor, Patrick Y Wen, Nancy U Lin, Alan J Grodzinsky, Dai Fukumura, Peigen Huang, James W Baish, Timothy P Padera, Lance L Munn, Rakesh K Jain
Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium. Nature biomedical engineering 3 (3) (2019)
Giorgio Seano, Rakesh K Jain
Vessel co-option in glioblastoma: emerging insights and opportunities. Angiogenesis 23 (1) (2019)
Joseph A Flores-Toro, Defang Luo, Adithya Gopinath, Matthew R Sarkisian, James J Campbell, Israel F Charo, Rajinder Singh, Thomas J Schall, Meenal Datta, Rakesh K Jain, Duane A Mitchell, Jeffrey K Harrison
CCR2 inhibition reduces tumor myeloid cells and unmasks a checkpoint inhibitor effect to slow progression of resistant murine gliomas. Proceedings of the National Academy of Sciences of the United States of America 117 (2) (2019)
Karen Olivia Dixon, Michelle Schorer, James T Nevin, Yassaman Etminan, Zohreh Amoozgar, Takaaki Kondo, Sema Kurtulus, Nasim Kassam, Raymond A Sobel, Dai Fukumura, Rakesh K Jain, Ana C Anderson, Vijay K Kuchroo, Nicole Joller
Functional Anti-TIGIT Antibodies Regulate Development of Autoimmunity and Antitumor Immunity. Journal of immunology (Baltimore, Md. : 1950) 200 (8) (2018)
David P Kodack, Vasileios Askoxylakis, Gino B Ferraro, Qing Sheng, Mark Badeaux, Shom Goel, Xiaolong Qi, Ram C Shankaraiah, Z Alexander Cao, Rakesh R Ramjiawan, Divya Bezwada, Bhushankumar Patel, Youngchul Song, Carlotta Costa, Kamila Naxerova, Christina S F Wong, Jonas Kloepper, Rita Das, Angela Tam, Jantima Tanboon, Dan G Duda, C Ryan Miller, Marni B Siegel, Carey K Anders, Melinda E Sanders, M Valeria Estrada, Robert Schlegel, Carlos L Arteaga, Elena Brachtel, Alan Huang, Dai Fukumura, Jeffrey A Engelman, Rakesh K Jain
The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation. Science translational medicine 9 (391) (2018)
Kamila Naxerova, Johannes G Reiter, Elena Brachtel, Jochen K Lennerz, Marc van de Wetering, Andrew Rowan, Tianxi Cai, Hans Clevers, Charles Swanton, Martin A Nowak, Stephen J Elledge, Rakesh K Jain
Origins of lymphatic and distant metastases in human colorectal cancer. Science (New York, N.Y.) 357 (6346) (2018)
Matthias Pinter, Rakesh K Jain
Targeting the renin-angiotensin system to improve cancer treatment: Implications for immunotherapy. Science translational medicine 9 (410) (2018)