Prognostic value of circulating tumour DNA during post-radiotherapy surveillance in locally advanced esophageal squamous cell carcinoma.
Xin WangNuo YuGuowei ChengTao ZhangJianyang WangLei DengJiao LiXiaotian ZhaoYang XuPeng YangNa BaiYin LiNan BiPublished in: Clinical and translational medicine (2022)
ctDNA was identified as a robust biomarker for early detection of disease progression and post-RT/CRT prognosis stratification in ESCC. Detectable ctDNA at week 4 of RT/CRT might indicate higher local recurrence risks, implying the potential clinical utility of ctDNA tests in guiding post-RT/CRT treatments for locoregional control in ESCC.
Keyphrases
- circulating tumor
- locally advanced
- cardiac resynchronization therapy
- rectal cancer
- squamous cell carcinoma
- cell free
- circulating tumor cells
- neoadjuvant chemotherapy
- radiation therapy
- human health
- single molecule
- left ventricular
- risk assessment
- randomized controlled trial
- radiation induced
- atrial fibrillation
- lymph node
- study protocol