Differential inflammatory responses of the native left and right ventricle associated with donor heart preservation.
Ienglam LeiWei HuangPeter A WardJordan S PoberGeorge TellidesGorav AilawadiFrancis D PaganiAndrew P LandstromZhong WangRichard M MortensenMarilia CascalhoJeffrey PlattYuqing Eugene ChenHugo Yu Kor LamPaul C TangPublished in: Physiological reports (2022)
Mouse hearts subjected to cold ischemia showed time-dependent contractile dysfunction and increased cell death, inflammatory cytokine expression and inflammasome expression that are greater in the LV than RV. However, IL-6 protein elevations and altered transcriptional profiles were similar in both ventricles. Similar changes are observed in human hearts.
Keyphrases
- poor prognosis
- cell death
- binding protein
- endothelial cells
- oxidative stress
- heart failure
- gene expression
- skeletal muscle
- transcription factor
- pulmonary hypertension
- long non coding rna
- induced pluripotent stem cells
- left ventricular
- signaling pathway
- protein protein
- amino acid
- congenital heart disease
- pulmonary arterial hypertension
- heat stress