Eligibility of Dapagliflozin and Empagliflozin in a Real-World Heart Failure Population.
Erik HåkanssonHelena NorbergSara SjälanderKrister LindmarkPublished in: Cardiovascular therapeutics (2021)
39-52% of patients with heart failure and reduced ejection fraction in this real-world heart failure population were eligible for SGLT2-inhibitor treatment, corresponding to 11-14% of all heart failure patients. Compared to trial participants, eligible real-world patients were significantly older with worse renal function, more atrial fibrillation, and less diabetes mellitus. Trial entry criteria exclude comparatively young and healthy patients, as well as comparatively old patients with more comorbid conditions.
Keyphrases
- heart failure
- end stage renal disease
- ejection fraction
- atrial fibrillation
- chronic kidney disease
- newly diagnosed
- study protocol
- left ventricular
- randomized controlled trial
- type diabetes
- phase iii
- patient reported outcomes
- skeletal muscle
- acute coronary syndrome
- adipose tissue
- venous thromboembolism
- coronary artery disease
- weight loss
- smoking cessation