NR1H4 rs35724 G>C variant modulates liver damage in nonalcoholic fatty liver disease.
Stefania GrimaudoPaola DongiovanniJussi PihlajamäkiMohammed EslamHannele Yki-JärvinenRosaria Maria PipitoneGuido BaselliCalogero CammàVito Di MarcoMarco EneaMiriam LongoGrazia PennisiDaniele PratiRossella ZitoAnna Ludovica FracanzaniAntonio CraxìJacob GeorgeStefano RomeoLuca Vittorio ValentiSalvatore PettaPublished in: Liver international : official journal of the International Association for the Study of the Liver (2021)
Increased hepatic FXR expression due to the NR1H4 rs35724 C allele is linked to higher serum cholesterol but protects against steatosis, steatohepatitis and liver fibrosis. The translational relevance of these results for patient risk stratification and FXR-targeted therapy warrants further investigation.