A comprehensive and perspective view of oncoprotein SET in cancer.
Buuvee BayarkhangaiSuzan NoureldinLiting YuNa ZhaoYaru GuHanmei XuChangying GuoPublished in: Cancer medicine (2018)
SET is a multifunctional oncoprotein which is ubiquitously expressed in all kinds of cells. The SET protein participates in many cellular processes including cell cycle, cell migration, apoptosis, transcription, and DNA repair. Accumulating evidence demonstrates that the expression and activity of SET correlate with cancer occurrence, metastasis, and prognosis. Therefore, the SET protein is regarded as a potential target for cancer therapy and several inhibitors are being developed for clinical use. Herein, we comprehensively review the physiological and pathological functions of SET as well as its structure-function relationship. Additionally, the regulatory mechanisms of SET at both transcriptional and posttranslational levels are also discussed.
Keyphrases
- cell cycle
- dna repair
- cancer therapy
- cell migration
- transcription factor
- cell cycle arrest
- papillary thyroid
- cell proliferation
- dna damage
- poor prognosis
- gene expression
- induced apoptosis
- risk assessment
- binding protein
- squamous cell
- small molecule
- endoplasmic reticulum stress
- amino acid
- climate change
- protein protein
- pi k akt