Pain Experience in Pancreatitis: Strong Association of Genetic Risk Loci for Anxiety and PTSD in Patients With Severe, Constant, and Constant-Severe Pain.
Ellyn K DunbarPhil J GreerStephen T AmannSamer AlkaadePeter BanksRandall BrandDarwin L ConwellChristopher E ForsmarkTimothy B GardnerNalini M GudaMichele D LewisJorge D MachicadoThiruvengadam MunirajGeorgios I PapachristouJoseph RomagnuoloBimaljit S SandhuStuart ShermanAdam SlivkaC Mel WilcoxDhiraj YadavDavid C Whitcombnull nullPublished in: The American journal of gastroenterology (2021)
A component of constant and severe pain in patients with RAP and CP is associated with genetic predisposition to anxiety and PTSD. Identification of patients at risk eligible for trials of targeted treatment as a component of a multidisciplinary pain management strategy should be formally evaluated.
Keyphrases
- pain management
- chronic pain
- genome wide
- early onset
- neuropathic pain
- end stage renal disease
- newly diagnosed
- ejection fraction
- social support
- posttraumatic stress disorder
- sleep quality
- prognostic factors
- gene expression
- physical activity
- patient reported outcomes
- combination therapy
- smoking cessation
- postoperative pain
- bioinformatics analysis