New roles for AP-1/JUNB in cell cycle control and tumorigenic cell invasion via regulation of cyclin E1 and TGF-β2.

Beatriz Pérez-BenaventeAlihamze FathinajafabadiLorena de la FuenteCarolina GandíaArantxa Martínez-FérrizJosé Miguel Pardo-SánchezLara MiliánAna ConesaOctavio A RomeroJulián CarreteroRune MatthiesenIsabelle Jariel-EncontreMarc PiechaczykRosa Farràs

Published in: Genome biology (2022)

Our results reveal novel functions for JUNB in cell proliferation and tumor aggressiveness through regulation of cyclin E1 and TGF-β2 expression, which might be exploited for cancer prognosis and therapy.

Keyphrases

cell cycle
cell proliferation
transforming growth factor
poor prognosis
papillary thyroid
transcription factor
squamous cell
genome wide
single cell
squamous cell carcinoma
pi k akt
stem cells
binding protein
young adults
bone marrow