Dapagliflozin Prevents NOX- and SGLT2-Dependent Oxidative Stress in Lens Cells Exposed to Fructose-Induced Diabetes Mellitus.

Ying-Ying ChenTsung-Tien WuChiu-Yi HoTung-Chen YehGwo-Ching SunYa-Hsin KungTzyy-Yue WongChing-Jiunn TsengPei-Wen Cheng

Published in: International journal of molecular sciences (2019)

In rats with fructose-induced DM, dapagliflozin downregulates RAGE-induced NADPH oxidase expression in LECs via the inactivation of GLUTs and a reduction in ROS generation. These novel findings suggest that the SGLT2 inhibitor dapagliflozin may be a candidate for the pharmacological prevention of cataracts in patients with DM.

Keyphrases

diabetic rats
oxidative stress
high glucose
induced apoptosis
drug induced
poor prognosis
metabolic syndrome
endoplasmic reticulum stress
adipose tissue
cataract surgery
heat shock protein