Protective effects of 4-geranyloxy-2,6-dihydroxybenzophenonel on DSS-induced ulcerative colitis in mice via regulation of cAMP/PKA/CREB and NF-κB signaling pathways.
Mingqiang WangYanzhen LiJianhui SuJingyan BaiZhongxiang ZhaoZhanghua SunPublished in: Phytotherapy research : PTR (2022)
Hypericum sampsonii Hance has traditionally been used to treat enteritis and diarrhea. As one of the main benzophenones isolated from H. sampsonii, 4-geranyloxy-2,6-dihydroxybenzophenonel (4-GDB) has been shown to possess anti-inflammatory effects. However, the therapeutic effect and potential mechanisms of 4-GDB in ulcerative colitis (UC) remain unclear. This study aimed to evaluate the role of 4-GDB in UC using a dextran sulfate sodium-induced colitis mouse model. Intragastric administration of 4-GDB (20 mg/kg/day) for 8 days significantly attenuated colonic injury, reduced the expression of inflammatory mediators, and improved colonic barrier function in mice with colitis. Furthermore, in vivo and in vitro experiments indicated that 4-GDB could activate cAMP/PKA/CREB and inhibit the NF-κB pathway. Collectively, 4-GDB may be a potential agent for treating UC by regulating the cAMP/PKA/CREB and NF-κB pathways.
Keyphrases
- ulcerative colitis
- signaling pathway
- pi k akt
- lps induced
- binding protein
- oxidative stress
- mouse model
- nuclear factor
- high fat diet induced
- epithelial mesenchymal transition
- poor prognosis
- diabetic rats
- protein kinase
- induced apoptosis
- human health
- inflammatory response
- high glucose
- type diabetes
- climate change
- insulin resistance
- adipose tissue
- immune response
- irritable bowel syndrome
- long non coding rna