Vascular Early Response Gene (Verge) is an immediate early gene (IEG) that is up-regulated in endothelial cells in response to a number of stressors, including ischemic stroke. Endothelial cell lines that stably express Verge show enhanced permeability. Increased Verge expression has also been associated with blood brain barrier breakdown. In this study we investigated the role of Verge in ischemic injury induced by middle cerebral artery occlusion (MCAO) in both Verge knockout (KO) and wild type (WT) mice. Verge KO mice had significantly less cerebral edema formation after MCAO compared to WT mice. However, stroke outcome (infarct size and neurological deficit scores) evaluated at either 24 or 72 hours after stroke showed no differences between the two genotypes. Verge deletion leads to decreased edema formation after ischemia; however acute stroke outcomes were unchanged.
Keyphrases
- wild type
- blood brain barrier
- endothelial cells
- cerebral ischemia
- middle cerebral artery
- atrial fibrillation
- copy number
- high fat diet induced
- genome wide
- poor prognosis
- subarachnoid hemorrhage
- heart failure
- internal carotid artery
- type diabetes
- acute myocardial infarction
- high glucose
- coronary artery disease
- gene expression
- ischemia reperfusion injury
- vascular endothelial growth factor
- insulin resistance
- dna methylation
- acute coronary syndrome
- atomic force microscopy