Determination of tacrolimus in human whole blood in kidney transplant recipients using a rapid and specific LC-MS/MS method.
Tran Ba HieuNguyen Manh DungPham Quoc ToanTruong Quy KienNguyen Van DucViet Thang LePham Van TranVu Quang HopNguyen Minh PhuongNguyen Huu BenNguyen Van KhoiTran Trung NghiaVu Dinh DungNguyen Van ThinhDinh Thi Thu HangChu Van MenDao Duc LongHoang Xuan SuPublished in: Journal of clinical laboratory analysis (2023)
The LC-MS/MS method was validated for the accurate determination of TAC in human whole blood. The comparison of tacrolimus concentrations measured by the LC-MS/MS with CMIA showed a good correlation and agreement of two methods, suggesting LC-MS/MS should be used routinely to monitor TAC concentrations in kidney transplant patients.