A candidate pathogenic gene, zinc finger gene 217 (ZNF217), may contribute to polycystic ovary syndrome through prostaglandin E2.
Junyu ZhaiShang LiXiaoyue ChengZi-Jiang ChenWeiping LiYanzhi DuPublished in: Acta obstetricia et gynecologica Scandinavica (2019)
Decreased ZNF217 expression in granulosa cells of women with polycystic ovary syndrome induced inflammation via PGE2, and PGE2 inhibited ZNF217 expression to establish a feedback loop. This mechanism might account for the pathogenesis of polycystic ovary syndrome.
Keyphrases
- polycystic ovary syndrome
- insulin resistance
- poor prognosis
- induced apoptosis
- copy number
- genome wide
- oxidative stress
- binding protein
- transcription factor
- genome wide identification
- high glucose
- metabolic syndrome
- diabetic rats
- adipose tissue
- long non coding rna
- gene expression
- pregnant women
- endoplasmic reticulum stress
- signaling pathway