Genome-wide discovery, and computational and transcriptional characterization of an AIG gene family in the freshwater snail Biomphalaria glabrata, a vector for Schistosoma mansoni.
Lijun LuEric S LokerSi-Ming ZhangSarah K BuddenborgLijing BuPublished in: BMC genomics (2020)
The AIG genes of B. glabrata exhibit expansion in both numbers and potential functions, differ markedly in expression between strains varying in susceptibility to schistosomes, and are responsive to immune challenge. These features provide strong impetus to further explore the functional role of AIG genes in the defense responses of B. glabrata, including to suppress or support the development of medically relevant S. mansoni parasites.
Keyphrases
- genome wide
- candida albicans
- dna methylation
- poor prognosis
- copy number
- epithelial mesenchymal transition
- small molecule
- escherichia coli
- genome wide identification
- transcription factor
- gene expression
- bioinformatics analysis
- high throughput
- cancer therapy
- long non coding rna
- oxidative stress
- drug delivery
- human health
- genome wide analysis
- heat shock protein