Prospective, randomized, controlled trial assessing the effects of a driving pressure-limiting strategy for patients with acute respiratory distress syndrome due to community-acquired pneumonia (STAMINA trial): protocol and statistical analysis plan.
null nullIsrael Silva MaiaFernando Azevedo MedradoLucas TramujasBruno Martins TomaziniJúlia Souza OliveiraErica Regina Ribeiro SadyLetícia Galvão BarbanteMarina Lazzari NicolaRodrigo Magalhães GurgelLucas Petri DamianiKarina Leal NegrelliTamiris Abait MirandaEliana SantucciNanci ValeisLigia Nasi LaranjeiraGlauco Adrieno WestphalRuthy Perotto FernandesCássio Luis ZandonaiMariângela Pimentel PincelliRodrigo Cruvinel FigueiredoCíntia Loss Sartori BustamanteLuiz Fernando NorbinEmerson BoschiRafael LessaMarcelo Luz Pereira RomanoMieko Cláudia MiuraMeton Soares de Alencar FilhoVicente Cés de Souza DantasPriscilla Alves BarretoMauro Esteves HernandesCíntia Magalhães Carvalho GrionAlexandre Sanches LaranjeiraAna Luiza MezzarobaMarina Mônica BahlAna Carolina StarkeRodrigo Santos BiondiFelipe Dal PizzolEliana Bernadete CaserMarlus Muri ThompsonAndrea Allegrini PadialViviane Cordeiro VeigaRodrigo Thot LeiteGustavo AraújoMário GuimarãesPriscilla de Aquino MartinsFábio Holanda LacerdaConrado Roberto Hoffman FilhoLivia Maria Garcia MelroEduardo PachecoGustavo Adolfo Ospina-TásconJuliana Carvalho FerreiraFabricio Jocundo Calado FreiresFlávia Ribeiro MachadoAlexandre Biasi CavalcantiFernando Godinho ZampieriPublished in: Critical care science (2024)
STAMINA is designed to provide evidence on whether a driving pressure-limiting strategy is superior to the ARDSNet low-positive end-expiratory pressure table strategy for increasing the number of ventilator-free days within 28 days in patients with moderate-to-severe acute respiratory distress syndrome. Here, we describe the rationale, design and status of the trial.