N-Methyl-D-Aspartate Receptor Antibodies in Autoimmune Encephalopathy Alter Oligodendrocyte Function.

Carlos MatuteAna PalmaMaría Paz Serrano-RegalEstibaliz MaudesSumanta BarmanMaría Victoria Sánchez-GómezMaría DomercqNorbert GoebelsJosep O Dalmau

Published in: Annals of neurology (2020)

Antibodies from patients with anti-NMDAR encephalitis specifically alter the function of NMDARs in oligodendrocytes, causing a decrease of expression of GLUT1. Considering that normal GLUT1 expression in oligodendrocytes and myelin is needed to metabolically support axonal function, the findings suggest a link between antibody-mediated dysfunction of NMDARs in oligodendrocytes and the white matter alterations reported in patients with this disorder. ANN NEUROL 2020;87:670-676.

Keyphrases

white matter
poor prognosis

multiple sclerosis

oxidative stress

early onset