Immunoglobulins G from patients with ANCA-associated vasculitis are atypically glycosylated in both the Fc and Fab regions and the relation to disease activity.
Olivier M LardinoisLeesa J DeterdingJacob J HessCaroline J PoultonCandace D HendersonJ Charles JennettePatrick H NachmanRonald J FalkPublished in: PloS one (2019)
Significant differences exist between MPO and PR3-ANCA regarding the changes in amounts and types of glycans on Fc fragment and the association with disease activity. These differences may contribute to significant clinical difference in the disease course observed between the two diseases.