Altered functional brain states predict cognitive decline 5 years after a clinically isolated syndrome.
Ismail KoubiyrTommy Aa BroedersMathilde DeloireBruno BrochetThomas TourdiasJeroen Jg GeurtsMenno Michiel SchoonheimAurélie RuetPublished in: Multiple sclerosis (Houndmills, Basingstoke, England) (2022)
Patients with early MS showed reduced functional network dynamics at baseline. Longitudinal changes showed longer time spent in a state of low FC but less time spent and more connectivity disturbance in more integrative states with high within- and between-network FC. Disturbed FC within this more integrative state was predictive of future cognitive decline.