Enantioselective Synthesis of δ-Carbolinones via N-Heterocyclic Carbene Catalysis.

An enantioselective synthesis of δ-carbolinones was accomplished through N-heterocyclic carbene-catalyzed formal [3+3] annulation of 3-aminoindoles with 2-bromoenals. This protocol offers a rapid and efficient synthetic approach for accessing a wide range of enantioenriched structurally interesting δ-carbolinones under mild reaction conditions.