PHACTR-1 (Phosphatase and Actin Regulator 1) Deficiency in Either Endothelial or Smooth Muscle Cells Does Not Predispose Mice to Nonatherosclerotic Arteriopathies in 3 Transgenic Mice.
Sebastien RubinPauline BougaranSoizic MartinAlice AbélanetValentin DelobelMathieu PernotSylvie JeanningrosMarie-Lise BatsChristian CombePascale DufourcqStephanie DebetteThierry CouffinhalMuralidharan SargurupremrajPublished in: Arteriosclerosis, thrombosis, and vascular biology (2022)
Loss of PHACTR-1 function in the cells involved in vascular physiology does not appear to induce a pathological vascular phenotype. The in vivo effect of the intronic variation described in genome-wide association studies is unlikely to involve downregulation in PHACTR-1 expression.