Toll-Like Receptor 3 Mediates Aortic Stenosis Through a Conserved Mechanism of Calcification.
Can Gollmann-TepeköylüMichael GraberJakob HirschSophia MairAndreas NaschbergerLeo PölzlFelix NägeleElke KirchmairGerald DegenhartEgon DemetzRichard HilbeHao-Yu ChenJames C EngertAnna BoehmNadja FranzDaniela LobenweinDaniela LenerChristiane FuchsAnna WeihsSonja TöchterleGeorg-Friedrich VogelVictor SchweigerJonas EderPeter PietschmannMarkus SeifertFlorian KronenbergStefan CoassinMichael BlumerHubert HacklDirk MeyerGudrun Maria FeuchtnerRudolf KirchmairJakob TroppmairMarkus KraneGuenter WeissSotirios TsimikasGeorge ThanassoulisMichael GrimmBernhard RuppLukas A HuberShen-Ying ZhangJean-Laurent CasanovaIvan TancevskiJohannes HolfeldPublished in: Circulation (2023)
This study identifies the BGN-TLR3-IFNAR1 axis as an evolutionarily conserved pathway governing calcification of the aortic valve and reveals a potential therapeutic target to prevent CAVD.
Keyphrases
- aortic valve
- toll like receptor
- aortic stenosis
- transcatheter aortic valve replacement
- aortic valve replacement
- transcatheter aortic valve implantation
- ejection fraction
- inflammatory response
- nuclear factor
- immune response
- left ventricular
- chronic kidney disease
- transcription factor
- coronary artery disease
- genome wide
- heart failure
- climate change
- atrial fibrillation