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In Vivo Antibacterial Activity of Acetazolamide.

Nader S AbutalebAhmed ElkashifDaniel P FlahertyMohamed N Seleem
Published in: Antimicrobial agents and chemotherapy (2021)
Vancomycin-resistant enterococci (VRE) represent a major public health threat that requires the development of new therapeutics. In the present study, acetazolamide (AZM) was evaluated against enterococci. It inhibited different enterococcal strains tested at clinically achievable concentrations. Moreover, AZM outperformed linezolid, the drug of choice for VRE infections, in two in vivo VRE mouse models-murine colonization-reduction and VRE septicemia. Collectively, these results indicate that AZM warrants consideration as a promising treatment option for VRE infections.
Keyphrases
  • methicillin resistant staphylococcus aureus
  • public health
  • small molecule
  • staphylococcus aureus
  • combination therapy
  • decision making