Molecular subtypes of high grade serous ovarian cancer across racial groups and gene expression platforms.

Natalie R Davidson Mollie E Barnard Ariel A HippenAmy CampbellCourtney JohnsonGregory P WayBrian K DalleyAndrew BerchuckLucas A Salas Lauren C PeresJeffrey R MarksJoellen M SchildkrautCasey S GreeneJennifer A Doherty

Published in: bioRxiv : the preprint server for biology (2023)

A single pipeline can be used to assign gene expression subtypes to HGSC with array-based or RNA-Seq gene expression data. We observed that while the prevalence of the immunoreactive subtype was higher, and the prevalence of the differentiated subtype was lower among Black individuals compared to White individuals, subtype-specific survival was similar.

Keyphrases

gene expression
high grade
rna seq
dna methylation
single cell
risk factors
low grade
high resolution
high throughput
mass spectrometry
machine learning
free survival
data analysis