PDE5 inhibitor drugs for use in dementia.

Atticus H HainsworthOttavio ArancioFanny M ElahiJeremy D IsaacsFeixiong Cheng

Published in: Alzheimer's & dementia (New York, N. Y.) (2023)

Potent phosphodiesterase-5 (PDE5) inhibitors are in clinical use as vasodilators.In animals PDE5 inhibitors enhance synaptic function and cognitive ability.In humans the PDE5 inhibitor sildenafil is associated with reduced risk of Alzheimer's disease.Licensed PDE5 inhibitors have potential for repurposing in dementia.Prospective clinical trials of PDE5 inhibitors are warranted.

Keyphrases

clinical trial
mild cognitive impairment
randomized controlled trial
pulmonary hypertension
risk assessment
study protocol
phase ii
double blind
drug discovery
placebo controlled