Breast milk apelin level increases with maternal obesity and high-fat feeding during lactation.
Lucie MarousezSandy HanssensLaura ButruilleCéline PetitCharlène PourpeCapucine BesengezThameur RakzaLaurent StormePhilippe DeruelleJean LesageDelphine EberléPublished in: International journal of obesity (2005) (2021)
Our study indicates that BM apelin levels increase with long- and short-term overnutrition, possibly via maternal hyperinsulinemia and transcriptional upregulation of MG apelin expression in myoepithelial cells. Apelin regulates many physiological processes, including energy metabolism, digestive function, and development. Further studies are needed to unravel the consequences of such changes in offspring development.
Keyphrases
- poor prognosis
- induced apoptosis
- birth weight
- insulin resistance
- metabolic syndrome
- type diabetes
- pregnancy outcomes
- gene expression
- weight gain
- high fat diet
- weight loss
- signaling pathway
- cell proliferation
- transcription factor
- long non coding rna
- pregnant women
- human milk
- endoplasmic reticulum stress
- high fat diet induced
- adipose tissue
- dairy cows
- skeletal muscle
- preterm birth
- pi k akt
- heat shock protein