The Phenomenon of Antiretroviral Drug Resistance in the Context of Human Immunodeficiency Virus Treatment: Dynamic and Ever Evolving Subject Matter.
Miruna-Maria ApetroaeiBruno Ștefan VelescuMarina Ionela Ilie NedeaCristina Elena Dinu-PîrvuDoina DrăgănescuAnca Ionela FâcăDenisa Ioana UdeanuAndreea Letitia ArsenePublished in: Biomedicines (2024)
Human immunodeficiency virus (HIV) is a significant global health issue that affects a substantial number of individuals across the globe, with a total of 39 million individuals living with HIV/AIDS. ART has resulted in a reduction in HIV-related mortality. Nevertheless, the issue of medication resistance is a significant obstacle in the management of HIV/AIDS. The unique genetic composition of HIV enables it to undergo rapid mutations and adapt, leading to the emergence of drug-resistant forms. The development of drug resistance can be attributed to various circumstances, including noncompliance with treatment regimens, insufficient dosage, interactions between drugs, viral mutations, preexposure prophylactics, and transmission from mother to child. It is therefore essential to comprehend the molecular components of HIV and the mechanisms of antiretroviral medications to devise efficacious treatment options for HIV/AIDS.
Keyphrases
- hiv aids
- human immunodeficiency virus
- antiretroviral therapy
- hiv infected
- hiv positive
- hiv infected patients
- drug resistant
- hepatitis c virus
- global health
- multidrug resistant
- healthcare
- sars cov
- cardiovascular disease
- quantum dots
- cardiovascular events
- acinetobacter baumannii
- combination therapy
- dna methylation
- type diabetes
- coronary artery disease
- sensitive detection
- adverse drug
- drug induced
- single molecule
- cystic fibrosis