A genome-wide association study of bronchodilator response in participants of European and African ancestry from six independent cohorts.

Jessica D GereigeHanfei XuVictor E OrtegaMichael H ChoMing LiuPhuwanat SakornsakolpatEdwin K SilvermanTerri H BeatyBruce E MillerPer BakkeAmund GulsvikCraig P HershJarrett D Morrownull nullElizabeth J AmplefordGregory A HawkinsEugene R BleeckerDeborah A MeyersStephen P PetersJuan C CeledónKelan TantisiraJiang LiJosée DupuisGeorge T O'Connor

Published in: ERJ open research (2022)

Ancestry-stratified and ancestry-combined GWAS meta-analyses of over 14 000 participants did not identify genetic variants associated with BDR at the genome-wide significance threshold, although a less stringent threshold identified three variants showing suggestive evidence of association. A common definition and protocol for measuring BDR in research may improve future efforts to identify variants associated with BDR.

Keyphrases

genome wide association study
meta analyses
copy number
genome wide
randomized controlled trial
systematic review
dna methylation
current status
gene expression