Roles of Therapeutic Bioactive Compounds in Hepatocellular Carcinoma.
Divya JainYogesh MurtiWasi Ullah KhanRajib HossainMohammad Nabil HossainKrishn Kumar AgrawalRana Azeem AshrafMuhammad Torequl IslamPracheta JanmedaYasaman TaheriMohammed Mansour AlshehriSevgi Durna DaştanBalakyz YeskaliyevaAliya KipchakbayevaJavad Sharifi RadWilliam Chi Shing ChoPublished in: Oxidative medicine and cellular longevity (2021)
Hepatocellular carcinoma (HCC) is due to poor prognosis and lack of availability of effective treatment. Novel therapeutic strategies will be the fine tuning of intracellular ROS signaling to effectively deprive cells of ROS-induced tumor-promoting events. This review discusses the generation of ROS, the major signaling their modulation in therapeutics. We explore some of the major pathways involved in HCC, which include the VEGF, MAPK/ERK, mTOR, FGF, and Ser/Thr kinase pathways. In this review, we study cornerstone on natural bioactive compounds with their effect on hepatocarcinomas. Furthermore, we focus on oxidative stress and FDA-approved signaling pathway inhibitors, along with chemotherapy and radiotherapy enhancers which with early evidence of success. While more in vivo testing is required to confirm the findings presented here, our findings will aid future nonclinical, preclinical, and clinical studies with these compounds, as well as inspire medicinal chemistry scientists to conduct appropriate research on this promising natural compound and their derivatives.
Keyphrases
- signaling pathway
- induced apoptosis
- poor prognosis
- oxidative stress
- reactive oxygen species
- dna damage
- pi k akt
- cell death
- cell cycle arrest
- diabetic rats
- long non coding rna
- cell proliferation
- locally advanced
- early stage
- epithelial mesenchymal transition
- small molecule
- air pollution
- endoplasmic reticulum stress
- ischemia reperfusion injury
- vascular endothelial growth factor
- endothelial cells
- high glucose
- current status
- squamous cell carcinoma
- cell therapy
- radiation induced
- combination therapy
- drug administration
- drug discovery